This web page was produced as an assignment for Genetics 564, and undergraduate course at UW-Madison.
Protein homologues
Homo sapiens (human)
Recombination activating gene 1 RAG1 Uniprot ID: P15918 FASTA Pan troglodytes (chimpanzee) Recombination activating gene 1 RAG1 Uniprot ID: H2Q3F4 FASTA Macaca mulatta (rhesus macaque) Recombination activating gene 1 RAG1 Uniprot ID: G7NDK1 FASTA Canis lupus familiaris (dog) Recombination activating gene 1 RAG1 Uniprot ID: E2RDF6 FASTA Bos Taurus (cow) Recombination activating gene 1 RAG1 Uniprot ID: F11MG60 FASTA Mus musculus (mouse) Recombination activating gene 1 Rag1 Uniprot ID: P15919 FASTA Anolis carolinensis (anole lizard) Recombination activating gene 1 RAG1 Uniprot ID: G1KDK1 FASTA Rattus norvegicus (brown rat) Recombination activating gene 1 Rag1 Uniprot ID: G3V6K9 FASTA Gallus gallus (chicken) Recombination activating gene 1 RAG1 Accession number: NP_001026359.1 FASTA Xenopus tropicalis (xenopus) Recombination activating gene 1 rag1 Uniprot ID: Q563W0 FASTA Danio rerio (zebrafish) Recombination activating gene 1 rag1 Accession number: NP_571464.1 FASTA Astyanax mexicanus (cave fish) Recombination activating gene 1 RAG1 Uniprot ID: W5LE49 FASTA Pelodiscus sinensis (Chinese softshell turtle) Recombination activating gene 1 RAG1 Uniprot ID: K7F194 FASTA Latimeria chalumnae (coelacanth) Recombination activating gene 1 rag1 Uniprot ID: H3A5N4 FASTA Anas platyrhynchos (duck) Recombination activating gene 1 RAG1 Uniprot ID: R0LZS8 FASTA Loxodonta africana (elephant) Recombination activating gene 1 RAG1 Uniprot ID: G3UKA0 FASTA Mustela putorius furo (ferret) Recombination activating gene 1 RAG1 Uniprot ID: M3Z8B8 FASTA Ficedula albicollis (flycatcher) Recombination activating gene 1 RAG1 Uniprot ID: U3KIY3 FASTA Takifugu rubripes (fugu) Recombination activating gene 1 RAG1 Uniprot ID: Q9W699 FASTA |
Nomascus leucogenys (gibbon) Recombination activating gene 1 RAG1 Uniprot ID: G1S8G7 FASTA Gorilla gorilla gorilla (gorilla) Recombination activating gene 1 RAG1 Uniprot ID: G3RBF2 FASTA Cavia porcellus (guinea pig) Recombination activating gene 1 RAG1 Uniprot ID: H0W9U1 FASTA Equus caballus (horse) Recombination activating gene 1 RAG1 Uniprot ID: F6WSB4 FASTA Callithrix jacchus (marmoset) Recombination activating gene 1 RAG1 Uniprot ID: F7ERX5 FASTA Oryzia latipes (medaka) Recombination activating gene 1 rag1 Uniprot ID: H2M917 FASTA Myotis lucifugus (microbat) Recombination activating gene 1 RAG1 Uniprot ID: FASTA Xiphophorus maculatus (platyfish) Recombination activating gene 1 rag1 Uniprot ID: M3ZF22 FASTA Lepus curpaeums (rabbit) Recombination activating gene 1 RAG1 Uniprot ID: G1TU62W5PL78 FASTA Ovis aries (sheep) Recombination activating gene 1 RAG1 Uniprot ID: W5PL78 FASTA Lepisosteus oculatus (spotted gar) Recombination activating gene 1 RAG1 Uniprot ID: W5LZ93 FASTA Sciurus carolinensis (squirrel) Recombination activating gene 1 RAG1 Uniprot ID: I3MY25 FASTA Sarcophilus harrisii (Tasmanian devil) Recombination activating gene 1 RAG-1 Uniprot ID: G3WMA4 FASTA Tetraodon nigroviridis (tetraodon) Recombination activating gene 1 rag1 Uniprot ID: H3D3P4 FASTA Oreochromis niloticus (tilapia) Recombination activating gene 1 rag1 Uniprot ID: I3KB69 FASTA Meleagris gallapavo (turkey) Recombination activating gene 1 RAG1 Uniprot ID: G1NRN5 FASTA Taeniopygia guttata (zebra finch) Recombination activating gene 1 RAG1 Uniprot ID: H0ZIP6 FASTA |
Discussion
RAG1 is central to the development of the adaptive immune system [1]. As such, organisms that have adaptive immune systems will have a version of this protein. The wide variety organisms can provide a large variety of potential study systems that could provide unique insights into how RAG1 functions. I will look at primarily at mouse models, as they have 90% homology and have mutant strains that are applicable to immune phenotypes.
References
1) Owen, J., Punt, J., Stranford, S., Jones, P., Kuby, J. (2013). Kuby Immunology (7th ed). New York : W.H. Freeman and Company